Job postings

[Holly Heaslet Soutter]

This discussion forum is for posting open positions for scientists. These positions include both academic and industrial jobs at all levels. Please include in your posting a close date so that listings are kept current.

[Holly Heaslet Soutter]

Principal Scientist, DMPK - Takeda San DiegoTakeda Pharmaceuticals North America, Inc.
Posted August 12, 2009

Description

OBJECTIVES:
Serve as DMPK and PK/PD expert to discovery project teams, provide input into research strategies and be involved in collaboration with other Takeda sites in advancing compounds to IND. Provide expertise in area of PK/PD data analysis, interpretation and study design, and to participate in core-level decision-making. This individual will be expected to present, promote and defend their ideas in cross-functional team settings, and influence critical strategic decisions in multiple therapeutic areas

ACCOUNTABILITIES:

* Conducts PK and PK/PD analysis during late stage lead optimization through early pre-clinical development, and collaborates in PK/PD and efficacy study design
* Develops robust PK/PD models to illustrate the relationship between PK, PD, and efficacy in animal efficacy models
* Predicts PK, efficacious dose, and optimal dosing schedule in humans
* Designs, executes, and reports key PK studies to support compound progression from lead optimization to clinical candidate selection
* Collaborates with chemists to address structure-DMPK relationship and improves DMPK properties during lead optimization
* Collaborates with safety assessment group on study design and provides toxicokinetic data analysis and interpretation
* Provides on-going PK/PD training and mentoring to TSD PK scientists and helps apply such knowledge to their respective discovery projects
* Effectively communicates results within and outside the organization in various ways such as presentations and publications
* Influences the course of projects, scientific methods and/or technical company direction; develops and executes innovative methodologies to influence research approaches and efforts; devises complex approaches to apply scientific knowledge to solve problems
* Independently designs complex experimental strategies to discover probable drug targets or candidates that address project goals; acts as a technical and management advisor to others; operates with substantial latitude for action or decision
* Identifies, proposes and develops new solutions to the discovery strategy; contributes to development of company's concepts and principles and achieves objectives in creative and effective ways; develops unique solutions to complex problems where analysis of situations or data requires an in-depth evaluation of multiple factors
* Manages other PhD's and/or Research Associates; typically a combination of direct and indirect reports; provides mentoring to all scientific staff
* Manages more than one project of broad scope and high degree of complexity
* Represents own research and may represent company research to senior leadership or for scientific collaborations or at an international scientific conference recognized in the therapeutic discipline

Requirements
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
* Ph.D. or Pharm. D. with emphasis in pharmacokinetics and PK/PD and minimum 8 years of relevant experience, OR
* MS in life science and minimum 14 years of relevant experience, OR
* BS in life science and minimum 17 years of relevant experience
* DMPK Leadership in advancing compounds through discovery into IND-enabling stage
* Proficiency in PK, PK/PD, PK/efficacy modeling using various software such as WinNonlin and NONMEM
* Thorough understanding of the commonly used approaches for human PK prediction, and hands-on experience in application to multiple discovery programs
* Successful experience in predicting human efficacious dose and assisting clinical dosing schedule optimization
* Experience in the therapeutic areas of Oncology, Inflammation or Metabolic Disease
* Demonstrated independent thought/creativity in science and success in coordinating and executing research to further corporate goals
* Demonstrated inter-disciplinary knowledge of drug discovery and ability to use this knowledge to influence project strategy
* Demonstrated ability to successfully direct multiple scientific endeavors simultaneously
* High-level technical skills, with demonstrated application and creativity
* Excellent communication, collaboration and multitasking skills and ability to work in a team setting
* High degree of scientific discretion/intuition
* Conveys ideas in an experimentally detailed yet scientifically concise manner
* Demonstrated proficiency at presentation of original work at conferences
* Competent in authorship of peer-reviewed scientific papers

PHYSICAL DEMANDS:
* Exposure to hazardous/toxic/dangerous chemicals
* Prolonged standing and/or sitting.

TRAVEL REQUIREMENTS:
* May travel to various domestic conferences or client sites, including overnight trips
* Some international travel may be required
* Requires a minimum of 2% travel

Submit your resume and start a quality career with Takeda!
We are an equal opportunity employer.
www.tpna.com
www.takedasd.com

[Holly Heaslet Soutter]

Principal Scientist, Protein Chemistry - Takeda San DiegoTakeda Pharmaceuticals North America, Inc.
Posted August 12, 2009

Description
OBJECTIVES:
Plays a leading and integration role in the protein purification team. Responsibilities encompass purification and characterization of recombinant proteins for X-ray crystallization or for screening assays in drug discovery programs as well as involvement in advancing the technical and scientific expertise of Structural Biology.

ACCOUNTABILITIES:

* Responsible for purification and characterization of challenging proteins and to transfer processes to junior protein chemists
* Provides technical support as it relates to protein recovery and purification to increase productivity for the department
* Identifies and experimentally customizes properties of purified recombinant proteins when necessary
* Provides interactive leadership for other protein chemists to significantly contribute to the success of departmental and company goals
* Provides motivation/inspiration to colleagues and consistently communicates with molecular biologists, protein chemists and crystallographers to optimize work flow
* Evaluates and reviews data, determines problem solutions, project priorities and future experiments in multidisciplinary setting
* Has broad responsibility for protein deliveries and crystallization and for how the research within structural biology integrates with wider range corporate goals
* Develops and contributes to company's intellectual property domain by way of patents and/or publications, often as principal author
* Has significant cross-functional depth and interacts with scientists across multiple TSD departments and other Takeda sites to advance research program needs
* Influences the course of projects, scientific methods and/or technical company direction; develops and executes innovative methodologies to influence research approaches and efforts; devises complex approaches to apply scientific knowledge to solve problems
* Identifies, proposes and develops new solutions to the discovery strategy; contributes to development of company's concepts and principles and achieves objectives in creative and effective ways; develops unique solutions to complex problems where analysis of situations or data requires an in-depth evaluation of multiple factors
* Manages more than one project of broad scope and high degree of complexity
* Represents own research and may represent company research to senior leadership or for scientific collaborations or at an international scientific conference recognized in the therapeutic discipline

Requirements
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:

* Ph.D. in life science with a minimum of 8 years of relevant experience, or
* M.S. in life science with a minimum of 14 years of relevant experience, or
* B.S. in life science with a minimum of 17 years of relevant experience
* Must have strong protein purification and analytical skills, and a thorough understanding of protein expression and purification method development
* Good verbal and written communication skills are essential
* Exhibits good leadership skills in driving scientific and strategic direction
* Demonstrated scientific creativity, initiative, independent thought, problem-solving capability, and a track record of productivity
* Research experience with multiple classes of therapeutic proteins is desirable

PHYSICAL DEMANDS:

* Exposure to hazardous/toxic/dangerous chemicals
* Working in cold room (4oC)

TRAVEL REQUIREMENTS:

* Ability to drive to or fly to various meetings or client sites, including overnight trips. Some international travel may be required.
* Requires approximately 1-5 % travel.

Submit your resume and start a quality career with Takeda!
We are an equal opportunity employer.
www.tpna.com
www.takedasd.com

[Holly Heaslet Soutter]

Senior Scientist, Purification - Takeda San FranciscoTakeda Pharmaceuticals North America, Inc.
Posted August 12, 2009

Description
OBJECTIVES:
Maintain state-of-the-art capabilities in the process development and purification of monoclonal antibodies at bench and pilot scale. Evaluate relevant leading edge technologies, and the establishment and operation of purification processes to support research and process development activities in the study of proteins of therapeutic interest. Lead technology transfer operations to support GMP protein purification and supporting the equipment and documentation requirements of a compliant development laboratory.

The successful candidate will have a leadership role in the purification group, mentoring and managing junior scientists and associates. The candidate will lead all antibody-related purification programs and serve as an area expert at relevant meetings, both internal and external. The incumbent will support development and management of the departmental budget and time lines in accordance with company goals to ensure success for Takeda's antibody programs.
ACCOUNTABILITIES:

* Identify, develop, implement state-of-the-art technology for the protein purification processes
* Design and conduct experiments, analyzes and interprets data
* Select appropriate tools and materials for the development of suitable cost-effective processes
* Provide creative solutions to product and process challenges
* Utilize statistical methods to design, assess performance, and characterize processes
* Supply pre-validation process characterization data and participates in the design of validation studies
* Support and may lead technology transfer operations to the manufacturing group or CMO's as appropriate
* Provide education, guidance, and leadership to junior members of the team
* Contribute to project teams as a functional expert
* Ensure maintenance of excellent documentation of all work, to include laboratory notebooks, SOPs, test methods, or any other appropriate documents
* Create reports and presentations to communicate experimental information to other department colleagues, or other appropriate interested parties, clearly, frequently, and in a well-thought out manner
* Stay abreast of current relevant scientific and technical literature and industry trends
* Ensure the maintenance of a safe and tidy laboratory environment in compliance with all Federal, State, and Takeda San Francisco requirements and expectations
* Good verbal communication skills and interpersonal skills are required. Must be able to participate in highly effective teams.
* Must be able to manage projects and personnel effectively with a record of success in these areas

Requirements
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:

* A PhD Biochemistry, Biochemical Engineering, or related fields with a minimum of 5 years of relevant industrial experience, as well as proven experience in purification process development and scale-up for monoclonal antibodies, is required.
* The qualified candidate will have hands-on purification processes for early clinical trials of therapeutic monoclonal antibodies.
* Specific knowledge and proficiency in antibody purification techniques from cell harvest to production of bulk drug substance is required, including appropriate harvesting techniques, concentration techniques, viral removal steps, and various suitable chromatography modes.
* Demonstrated ability to creatively solve problems
* Demonstrated ability to communicate, present information, and argue a case using scientific data required
* Fluency in the use of standard computer software required (e.g. MS Word, MS Excel, MS PowerPoint) required
* Knowledge and experience of performing studies and process development work in accordance with ICH and other regulatory guidance desired
* Experience filing Regulatory documents (e.g. INDs, BLAs) a definite plus
* Thorough understanding and application of industry documentation practices required
* Understanding of cGMP requirements desired
* Knowledge and understanding of the application of statistical principles and statistical software (e.g. JMP) in experimental design (DOE) and data analysis preferred

PHYSICAL DEMANDS:
* Manual dexterity required to operate office equipment (i.e. computers, phones, etc.).
* Carrying, handling and reaching for objects.
* Standing, walking, lifting up to 20 lbs

TRAVEL REQUIREMENTS:
* Willingness to travel to various meetings or client sites, including overnight trips. Some international travel may be required.
* Requires approximately 5% travel.

Submit your resume and start a quality career with Takeda!
We are an equal opportunity employer.
www.takedasf.com
www.tpna.com

[Holly Heaslet Soutter]

Science and Engineering Opportunities at D. E. Shaw Research


Dear Connecticut AWIS Members,

My name is Scott Eckert, and I am posting on behalf of D. E. Shaw Research (DESRES). We are currently recruiting outstanding scientists and engineers, and I was hoping you'd consider the opportunities here. Please feel free to contact me or send me your resume if you're interested.

DESRES is a scientific research group focusing primarily on molecular simulations involving proteins and other biological macromolecules of interest from both a scientific and a pharmaceutical perspective. For instance, our team has developed a massively parallel special-purpose supercomputer designed to supply unprecedented computational power in this field. This is an ambitious, long-term project with the potential to transform the process of drug discovery. We are seeking extraordinary computational chemists and biologists, engineers, and computer scientists, among others. A complete list of our open positions can be found on our website here:

http://www.deshawresearch.com/joining.html

If you have any interest (or if you're just curious about what we're doing), please feel free to get in touch with me directly at [e-mail].

I look forward to hearing from some of you soon!

Sincerely,
Scott